Speaker | Maria Giuseppina Bisogni |
Affiliation | Università di Pisa and INFN-Sez. Pisa |
Date | 2025-05-22 |
Time | 14:15 |
Venue | ON-SITE NEST Meeting Room
ONLINE https://tinyurl.com/NanoColloquia |
Host | Fabio Taddei |
FLASH radiotherapy (FLASH-RT) is an innovative cancer treatment that delivers ultra-high dose rates (≥40 Gy/s) in less than 200 ms. This irradiation modality elicits a biological effect called FLASH effect, that significantly reduces damage to normal tissues while maintaining tumor control. Despite promising preclinical results, the precise mechanisms underlying this effect remain unclear, with hypotheses including transient oxygen depletion and reactive oxygen species dynamics. The clinical implementation of FLASH-RT faces challenges such as compact radiation sources, accurate dosimetry and reliable equipment for beam monitoring and delivery. This lecture reviews the latest advancements, technological challenges and future directions for FLASH-RT in clinical practice.
Seminar realized in the framework of the funded projects:
-PNRR, Mission 4, Component 2, Monitor for flash therapy (MORSE)
-PNRR, Missione 4, Component 2, Ecosistemi dell’Innovazione – Tuscany Health230 Ecosystem (THE), Spoke 1 “Advanced Radiotherapies and Diagnostics in Oncology”
-Fondazione Pisa AOO "CLE"
Istituto Nanoscienze
Consiglio Nazionale delle Ricerche
PEC: protocollo.nano@pec.cnr.it
Partita IVA 02118311006
Piazza San Silvestro 12
56127 Pisa, Italy
phone +39 050 509418
fax +39 050 509550
Istituto Nanoscienze Consiglio Nazionale delle Ricerche
Piazza San Silvestro 12, I
56127 Pisa
phone +39 050 509525/418
fax +39 050 509550
via Campi 213/A, I
41125 Modena 7
phone +39 059 2055629
fax +39 059 2055651″
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