Melissa Santi

Short Bio

Permanent Researcher at Istituto Nanoscienze of Consiglio Nazionale delle Ricerche (NANO-CNR). Research project: identification of targeting peptides for the development of new innovative tools for treatment of different types of diseases.

2017-2019 Postdoc: Center for Nanotechnology Innovation, Istituto Italiano di Tecnologia.

2013-2017 PhD student in Molecular Biophysics, Scuola Normale Superiore (Pisa, Italy).

2010-2013 Master’s degree in Molecular and Industrial Biotechnologies, University of Pisa

2007-2010 Bachelor’s degree in Biological and Molecular Science (Biotechnology), University of Pisa

Research Interests

I am highly experienced biotechnologist in the field of nanoparticles formulation for delivery of different types of molecules. Through my experience, I have gained in-depth competence and widespread experience in formulation of new type of targeted nanoparticles that can be applied to different biological problems. I have also worked on development of new targeting sequences by means of different approaches that can be useful for targeted drug delivery systems.

Selected Recent Projects

Selected Publications

M. Santi, A. K. Mapanao, L. Biancalana, F. Marchetti, V. Voliani “Ruthenium arene complexes in the treatment of 3D models of Head and Neck Squamous Cell Carcinomas”. Eur. J. Med. Chem. (2020), 212, 113143; Doi: 10.1016/j.ejmech.2020.113143.

M. Santi, F. Finamore, A. Cecchettini, F. M. Santorelli, S. Doccini, S. Rocchiccioli, G. Signore “Protein Delivery by Peptide-Based Stealth Liposomes: A Biomolecular Insight into Enzyme Replacement Therapy”. Mol. Pharmaceutics (2020), 17, 12, 4510–4521; Doi: 10.1021/acs.molpharmaceut.0c00615.

M. Santi, A. K. Mapanao, D. Cassano, Y. Vlamidis, V. Cappello, V. Voliani “Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas”. Cancers (2020), 12(5), 1063; doi: 10.3390/cancers12051063.


P. Parlanti, A. Boni, G. Signore, M. Santi “Targeted Dendrimer-Coated Magnetic Nanoparticles for Selective Delivery of Therapeutics in Living Cells” Molecules (2020), 25(9), 2252; doi: 10.3390/molecules25092252.


D. Cassano, M. Santi, F. D’Autilia, A. K. Mapanao, S. Luin, V. Voliani “Photothermal effect by NIR-responsive excretable ultrasmall-in-nano architectures”. Material Horizons (2019) 6 (3), 531-537; Doi: 10.1039/C9MH00096H.


M. Santi, G. Maccari, P. Mereghetti, V. Voliani, S. Rocchiccioli, N. Ucciferri, S. Luin,G. Signore “Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization”. Bioconjugate Chemistry (2017) 28 (2), 471-480; Doi: 10.1021/acs.bioconjchem.6b00611.


D. Cassano, M. Santi, V. Cappello, S. Luin, G. Signore, V. Voliani “Biodegradable Passion Fruit-Like Nano-Architectures as Carriers for Cisplatin Prodrug”. Particles and Particles System Characterization (2016) 33, 818-824; Doi: 10.1002/ppsc.201600175