Born in Italy in 1989, she received her master’s degree in Molecular and Cellular Biology from the Biology Department of the University of Pisa (Italy) in 2014, and PhD in Biophysical Sciences from the Scuola Normale Superiore (Italy) in 2020. Currently, she is a post doc researcher of the Nanoscience Institute (Pisa, Italy) of the Italian National Research Council (CNR).
Her main research interests are: the development of a novel Enzyme Replacement Therapy (ERT) for the treatment of Krabbe disease (KD) based on nanomaterials, and the study of molecular mechanisms involved in the pathogenesis of KD, with focus on autophagy dysfunction.
"Brain-targeted enzyme loaded nanoparticles: a breach through the blood brain barrier for enzyme replacement therapy in Krabbe disease", Del Grosso A., Galliani M., Angella L., Santi M., Tonazzini I., Parlanti G., Signore G., & Cecchini M. (2019), Science Advances, Vol. 5, no. 11, eaax7462. IF 2020: 14,143.
"Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease", Del Grosso A., Angella L., Tonazzini I., Moscardini A., Giordano N., Caleo M., ... & Cecchini, M. (2019), Neurobiology of disease, 129, 195-207. IF 2020: 5,996.
"Chronic Lithium asministration in a mouse model for Ktabbe disease", Del Grosso A., Parlanti G., Angella L., Giordano N., Tonazzini I., Ottalagana E., Carpi S., Pellegrino R.M., Husam B.R A., Emiliani C., Caleo M., Cecchini M., JIMD reports (2021, October). IF 2020: 1,98.
"Lithium improves cell viability in psychosine‐treated MO3. 13 human oligodendrocyte cell line via autophagy activation", Del Grosso A., Antonini S., Angella, L., Tonazzini I., Signore G., & Cecchini M. (2016), Journal of neuroscience research, 94(11), 1246-1260. IF 2020: 4,164.
"Visual system impairment in a mouse model of Krabbe disease: the Twitcher mouse", Tonazzini I., Cerri S., Del Grosso A., Antonini S., Allegra M., Signore G., Caleo, M., Cecchini M., (2021). Biomolecules, 11(1),7). IF 2020: 4,879.
"Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease", Pellegrini D., Del Grosso A., Angella L., Giordano N., Dilillo M., Tonazzini I., ... & McDonnell, L. A. (2019), Molecular & Cellular Proteomics, 18(6), 1227-1241. IF 2020: 5,911.
"Capturing Metabolism-Dependent Solvent Dynamics in the Lumen of a Trafficking Lysosome", Begarani F., D'Autilia, F., Signore G., Del Grosso A., Cecchini M., Gratton E., ... & Cardarelli, F. (2019), ACS nano. IF 2020: 15,881.
Istituto Nanoscienze
Consiglio Nazionale delle Ricerche
PEC: protocollo.nano@pec.cnr.it
Partita IVA 02118311006
Piazza San Silvestro 12
56127 Pisa, Italy
phone +39 050 509418
fax +39 050 509550
Istituto Nanoscienze Consiglio Nazionale delle Ricerche
Piazza San Silvestro 12, I
56127 Pisa
phone +39 050 509525/418
fax +39 050 509550
via Campi 213/A, I
41125 Modena 7
phone +39 059 2055629
fax +39 059 2055651″
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