Giorgia Brancolini

  • CNR Researcher
  • giorgia.brancolini@nano.cnr.it
  • Modena
  • +39-059-2055333
Twitter Linkedin Facebook Globe

Short Bio

CNR Senior Researcher working for a decade on multi-scale modeling of Interfaces between Biomolecules and Nanomaterials, Biological Macromolecules and Proteins Folding Dynamics, using methods ranging from ab initio calculations to atomistic and coarse grained molecular dynamics. Currently PI of a PNRR Extended 2022 Network 13, EU Grant (One Health Basic and Translational Research Actions) and PI of National Grants (PRIN2020, CNR SEED) she is co-Inventor of and Italian patent deposit “Biosensore per la rilevazione di particelle virali” (2022) PI of several supercomputing projects (e.g. Oak Ridge (USA): CNMS2020-B-00433; HPC-Europa: 2019/ HPC177BQ0O). She teaches at the Department of Physics Univ. Modena currently “Chemical Physics of Biomolecules”, Master's degree in Physics. She is the author of ~40 peer-review papers, with h factor 18 (source: scopus/scholar), and contributed to ~20 conferences with invited talks.

Research Interests

Development of Anti-SARS-Cov2 Therapeutic Strategies; Design of Biosensors; Functionalized Metal Nanoparticles as Nanotheranostic Agents; Intrinsically Disordered Proteins.

 

Selected Recent Projects

2022-2025: PI of PE13 Spoke 5 PNRR "One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases" https://www.nano.cnr.it/research/fundamental-and-translational-nanobiophysics/
2021-2024: PI of RU PRIN2020 Project “Early Phase Preclinical Development of PACECOR, a Mutation-Independent Anti-SARS-Co2 Therapeutic Strategy”
2016-2018: PI of SEED CNR national project (GAE PUSEED04): “LOPE-DeveLopment of a Coarse Grained Model for Nanoparticle-Protein IntEractions.” CNR Seed’s Project. Granted Budget: 15.000 Euro. PI G. Brancolini [Development of a CG methodology to study the Nanoparticle-Protein interactions]

2020-2022: PI of Supercomputing project “Molecular strategies to inhibit the COVID-19-cell interaction” at ORNL, USA. CNMS2020-B-00433. Granted 1.000.000 CPU hours (2 years). [Developing an in silico strategy to design biological inhibitors of SARS-CoV-2]


Selected Publications

"The Conformational Dynamics of the Ligands Determines the Electronic Circular Dichronism of the Chiral Au38(SC2H4Ph)24 Cluster", Monti M., Brancolini G., Coccia E., Toffoli D., Fortunelli A., Corni S., Aschi M., and Stener M., in The Journal of Physical Chemistry Letters (2023)

"Combining enhanced sampling and deep learning dimensionality reduction for the study of the heat shock protein B8 and its pathological mutant K141E", Montepietra D., Cecconi C., and Brancolini G., RSC advances, (2022)

"Tuning gold-based surface functionalization for streptavidin detection: A combined simulative and experimental study", Dutta S., Gagliardi M., Bellucci L., Corni S., Cecchini M., and Brancolini G., Front Mol Biosci, (2022)

"Aggregation behaviour of nanoparticles: Revisiting the phase diagram of colloids", Bini M., Brancolini G., and Tozzini V., Front Mol Biosci, (2022)

"Role of Ionic Strength in the Formation of Stable Supramolecular Nanoparticle–Protein Conjugates for Biosensing", G. Brancolini, V. M. Rotello, and S. Corni, Int. J. Mol. Sci. (2022)

"Atomistic Simulations of Functionalized Nano-Materials for Biosensors Applications", S.Dutta, S Corni, and G Brancolini, Int J Mol Sci (2022)

"High affinity protein surface binding through co-engineering of nanoparticles and proteins", M. Ray, G. Brancolini, D.C. Luther, Z. Jiang, R. Cao-Milán, A.M. Cuadros, A. Burden, V. Clark, S. Rana, R. Mout, R.F. Landis, S. Corni, and V.M. Rotello,  Nanoscale (2022)

"Molecular Dynamics Simulations of a Catalytic Multivalent Peptide–Nanoparticle Complex", S. Dutta, S. Corni, and G. Brancolini, Int J Mol Sci. (2021)

"Low-resolution models for the interaction dynamics of coated gold nanoparticles with β2-microglobulin", G. Brancolini, H. Lopez, S. Corni, and V. Tozzini, Int J Mol Sci (2019)

G. Brancolini, V. Tozzini, "Building Minimalist Models for Functionalized Metal Nanoparticles", Front Mol Biosci (2019)

"Coarse Grained and Multi-scale modeling of biofunctionalized nanoparticles", V. Tozzini and G. Brancolini, Curr Opin Colloid In (2019)

"Protein and peptide interactions with nanostructured gold surfaces: a challenge for nanoscience", G. Brancolini, L. Bellucci, M.C. Maschio, R. Di Felice, and S. Corni, Curr Opin Colloid In (2019)

"Citrate stabilized Gold Nanoparticles interfere with Amyloid Fibril formation: D76N and N6 Variants", G. Brancolini, M.C. Maschio, C. Cantarutti, A. Corazza, F. Fogolari, S. Corni, G. Esposito, Nanoscale (2018)

"Probing the Influence of Citrate-Capped Gold Nanoparticles on an Amyloidogenic Protein", G. Brancolini, A. Corazza, M. Vuano, F. Fogolari, M.C. Mimmi, V. Bellotti, M. Stoppini, S. Corni, and G. Esposito, ACS Nano 2015

Istituto Nanoscienze 

Consiglio Nazionale delle Ricerche

 

PEC: protocollo.nano@pec.cnr.it

Partita IVA 02118311006

Facebook-f Instagram Twitter Linkedin
Pisa NEST

Piazza San Silvestro 12

56127 Pisa, Italy

phone +39 050 509418

fax +39 050 509550

segreteria.nest@nano.cnr.it

Modena S3
via Campi 213/A
41125 Modena, Italy
phone +39 059 2055629
fax +39 059 2055651
segreteria.s3@nano.cnr.it

Istituto Nanoscienze Consiglio Nazionale delle Ricerche

Facebook-f Instagram Twitter Linkedin
Pisa NEST

Piazza San Silvestro 12, I
56127 Pisa

phone +39 050 509525/418

fax +39 050 509550

Modena S3

via Campi 213/A, I 

41125 Modena 7

phone +39 059 2055629

fax +39 059 2055651″