Engineered Nano-Biomaterials: A New Dimension in Regenerative Medicine

Nano-biomaterials are categorized on the basis of their different size, structural dimension, chemical moiety, and architecture. Designing advanced nano-biomaterials with outstanding therapeutic features is of paramount importance in regenerative medicine. Nano-biomaterials have been engineered by using different temperatures, precursors and functionalized with therapeutic molecules. The utilization of nano-biomaterials such as nano-sheet and carbon spheres in combination with laser for targeted controlled delivery of different biomolecules has been evaluated. The hydrophobic aromatic drugs and organic fluorophores delivery to living cells by using vapor nanobubbles for controlled targeted delivery and bioimaging have tremendous potential in clinical applications. The stability and release efficacy of different drug delivery nanocarrier systems in biological barriers are critical phenomena for the success of ideal drug delivery. Furthermore, in recent years, it has been observed that microbial resistance develops faster than the invention of new antibiotics. There is an urgent need to design alternative antimicrobials nano-biomaterials to replace or enhance the therapeutic potential of antibiotics for treating a whole spectrum of bacterial infections related diseases. To overcome this problem worldwide bacteriophage-based therapeutics appears to be a potential alternative. Bacteriophage functionalized with nano-biomaterials shows excellent antibacterial and biofilm removal properties. The second part of the talk will be focused on designing the next generation bioactive hybrid polymeric nano-biomaterials involving chitosan, gelatin, ulvan, silk and their relevant hybrid formulations. The development of cationic polymeric systems for enhancing antimicrobial and mineralization ability for regenerative medicine is another important development in the field of regenerative medicine. The utilization of magnetized nano-biomaterials, which involves the utilization of biopolymers and magnetic nanoparticles, featuring magnetic gradients for potential utility in magnetic/electric-field assisted regenerative medicine