Riccardo Nifosì

Short Bio


1992-1997: Undergraduate fellowship from the Scuola Normale Superiore Pisa, Italy

1997: Laurea (MSc) in Physics from the University of Pisa, Italy. Supervisor: Prof. M. P. Tosi

2004: PhD in Physics from the Scuola Normale Superiore Pisa, Italy. Supervisors: Prof. F. Beltram and Dott. V. Tozzini. Title of the thesis: "Molecular Mechanisms of Green Fluorescent Protein Photophysics".


Professional experience

Jan 2002 - Jul 2004: Scholarship of the INFM on "Modeling Green Fluorescent Proteins with classical and ab-initio molecular dynamics".

Jul 2004 -Feb 2009: Tenure track research scientist at CNR-INFM NEST, Pisa, Italy

Feb 2009 - now: Research scientist at CNR-NANO NEST, Pisa, Italy

Research Interests

  • Molecular modelling of biomolecules
  • Design and simulation of fluorescent protein biosensors


Selected Recent Projects

PLINIOS: A molecular platform for intracellular nitric oxide sensing. PRIN PNRR 2022 (Project nr. P2022F4WR8) https://smfi.unipr.it/molecular-platform-intracellular-nitric-oxide-sensing

Selected Publications

Quantum computing algorithms: getting closer to critical problems in computational biology.
L. Marchetti, R. Nifosì, P. L. Martelli, E. Da Pozzo, V. Cappello, F. Banterle, M. L. Trincavelli, C. Martini, and M. D’Elia. Briefings in Bioinformatics, 23, bbac437 (2022).


Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants.
R. Amodeo, R. Nifosì, C. Giacomelli, C. Ravelli, L. La Rosa, A. Callegari, ML. Trincavelli, S. Mitola, S. Luin, L. Marchetti, BBA. Molecular cell research 1867, 118614. (2020).


The key to the yellow-to-cyan tuning in the green fluorescent protein family is polarisation.
R. Nifosì, B. Mennucci, C. Filippi. Phys Chem Chem Phys 21, 18988 (2019).


Role of Gln222 in Photoswitching of Aequorea Fluorescent Proteins: A Twisting and H-Bonding Affair?.
B. Storti,