Alessandro Mossa

CNR Post-Doc
alessandro.mossa@nano.cnr.it
Modena
+390592058118

Short Bio

M.Sc. Degree in Theoretical Physics at Università degli Studi di Torino (2000), Ph.D. in Mathematical Physics at SISSA (International School for Advanced Studies) in Trieste (2004). Since then, several post-Doc appointments around the world: Rice University in Houston, TX (2004-06), Universitat de Barcelona (2006-09), Aarhus Universitet (2010-12), Università degli Studi di Bari (2013-15), working on a variety of research topics, all of them connected to some aspect or another of Statistical Mechanics, mostly with an eye to biophysical applications (both theoretical and experimental).
After a seven-year hiatus as a Maths teacher in Firenze, I am back to full-time research, this time focused on multiscale modeling for drug design.

Research Interests

Protein folding: full-atom and coarse-grained computational methods
Single-molecule experiments in biophysics: modelization and data analysis
Optical tweezers experiments on proteins and nucleic acids
Active matter
Non-equilibrium statistical mechanics: fluctuation theorems
Theory of phase transitions

Selected Recent Projects

TITOLO PRIN2020 “Early Phase Preclinical Development of PACECOR, a Mutation-Independent Anti-SARS-Cov2 Therapeutic Strategy”

Selected Publications

A. Mossa and C. Cecconi, "A fit-less approach to the elasticity of the handles in optical tweezers experiments", Eur. Biophys. J. (2022).
Choudhary, A. Mossa, M. Jadhav, and C. Cecconi, “Bio-molecular applications of recent developments in optical tweezers”, Biomolecules 9 (2019), 23.
Cagnetta, G. Gonnella, A. Mossa, and S. Ruffo, "Strong anomalous diffusion of the phase of a chaotic pendulum", Europhys. Lett. 111 (2015), 10002.
Suma, G. Gonnella, G. Laghezza, A. Lamura, A. Mossa, and L.F. Cugliandolo, “Dynamics of a homogeneous active dumbbell system”, Phys. Rev. E 90 (2014), 052130.
O. Heidarsson, M.M. Naqvi, M.R. Otazo, A. Mossa, B.B. Kragelund, and C. Cecconi, "Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1", Proc. Natl Acad. Sci. USA 111 (2014), 13069-13074.
O. Heidarsson, M.R. Otazo, L. Bellucci, A. Mossa, A. Imparato, E. Paci, S. Corni, R. Di Felice, B.B. Kragelund, and C. Cecconi, "Single-molecule folding mechanism of an EF-hand neuronal calcium sensor", Structure 21 (2013), 1812-1821.
Alemany, A. Mossa, I. Junier, and F. Ritort, "Experimental free-energy measurements of kinetic molecular states using fluctuation theorems", Nature Phys. 8 (2012), 688-694.
Mossa, S. de Lorenzo, J.M. Huguet, and F. Ritort, "Measurement of work in single-molecule pulling experiments", J. Chem. Phys. 130 (2009), 234116.
Junier, A. Mossa, M. Manosas, and F. Ritort, "Recovery of free energy branches in single molecule experiments", Phys. Rev. Lett. 102 (2009), 070602.
Mossa and G. Mussardo, "Analytic properties of the free energy: The tricritical Ising model", J. Stat. Mech. (2008), P03010.
Mossa and C. Clementi, "Supersymmetric Langevin equation to explore free-energy landscapes", Phys. Rev. E 75 (2007), 046707.
Grinza and A. Mossa, "Topological origin of the phase transition in a model of DNA denaturation", Phys. Rev. Lett. 92 (2004), 158102.

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Alessandro Mossa

Short Bio

Research Interests

Selected Recent Projects

Selected Publications

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