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2. RATIONAL DESIGN OF FLUORESCENT REPORTERS AND RELATED IMAGING TECHNIQUES

 

Here special emphasis is focused on the development and characterization of novel tools for fluorescence microscopy, by combining computational modeling with experimental approaches. This activity represents a common platform for research lines detailed above. In this activity we are developing tools for the measure of parameters defining the intracellular environment, such as viscosity, polarity, and ionic composition. Some of these sensors are chemically synthetized, while others are genetically encoded and are obtained by molecular engineering of fluorescent proteins. We are also developing a novel sensor/effector for the control and reporting of conditional gene expression in cells and in entire organisms.


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